Use of Angiogenic Factors in the Conservative Management of Gestational Hypertension. Prospective, Randomised, Controlled Study.

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. One of the most controversial scenarios is gestational hypertension, a group of hypertensive disorders considered the mildest form of the pre-eclamptic spectrum, where current recommendations indicate termination of pregnancy at 37 weeks. However, the decision is based on outdated guidelines developed at a time when angiogenic factors were just beginning to be known. The purpose of the study is to use angiogenic factors as a guide to decide the most appropriate gestational age for termination of pregnancy in patients diagnosed with gestational hypertension.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Pregnant women between 24 and 40 weeks of gestation.

• Diagnosis of Gestational Hypertension based on ACOG criteria

• index sFlt-1/PIGF equal or below 33

Locations
Other Locations
Panama
Hospital Santo Tomas
RECRUITING
Panama City
Contact Information
Primary
Osvaldo Reyes, MD
oreyespanama@yahoo.es
+507 65655041
Backup
Gerado Cardenas, MD
drgacardenas@hotmial.com
Time Frame
Start Date: 2024-06-01
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 150
Treatments
Experimental: 39 weeks
Patients with gestational hypertension and angiogenic factors (sFlt-1/PIGF) below 33 will be evaluated weekly until 39 weeks, when termination of pregnancy will be scheduled.
Active_comparator: 37 weeks
Patients with gestational hypertension and angiogenic factors (sFlt-1/PIGF) below 33 will be evaluated weekly until 37 weeks, when termination of pregnancy will be scheduled.
Related Therapeutic Areas
Sponsors
Leads: Saint Thomas Hospital, Panama

This content was sourced from clinicaltrials.gov