Redirecting Poor Sleep Drivers of Early Cardiovascular Disease

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Sleep health is a critical component of cardiovascular well-being, and poor sleep has been linked with increased risk for all-cause mortality including cardiovascular disease (CVD). Moreover, many individuals within a population may have underlying, subclinical cardiovascular conditions, such as hypertension and arterial stiffness, and these may risk progressing to advanced CVD when coupled with inadequate sleep duration and quality. Given that Singapore ranks as the third most sleep-deprived city globally, understanding the relationship between sleep health and the prevalence and progression of CVD becomes increasingly important for population health. In addition, depression and psychological stress could also lead to poorer cardiovascular health by increasing blood cholesterol, blood sugar and blood pressure, and could also be directly related to or arise as a result of poor sleep. The aim of the current study is to track sleep and mental health using a combination of objective sleep tracking (Oura ring) and smartphone-based questionnaires (EMA), and examine their associations with detailed cardiovascular health data collected by the project RESET (Redirecting Immune, Lipid and Metabolic Drivers of Early Cardiovascular Disease).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 70
Healthy Volunteers: f
View:

• Willing to wear a ring

• Have any of the following conditions:

‣ High blood pressure

⁃ High cholesterol

⁃ Fatty liver

⁃ Family history of heart diseases or stroke.

⁃ Obesity

Locations
Other Locations
Singapore
National University of Singapore
RECRUITING
Singapore
Contact Information
Primary
Ju Lynn Ong, PhD
julynn.ong@nus.edu.sg
+6566015238
Backup
Gizem Yilmaz, PhD
gizem.yilmaz@nus.edu.sg
+6566015238
Time Frame
Start Date: 2025-03-24
Estimated Completion Date: 2027-12
Participants
Target number of participants: 1500
Treatments
Participants from RESET
Interested participants will be drawn from the RESET cohort which includes South-East Asians aged 40-70 years with no prior manifest atherosclerotic cardiovascular disease.
Related Therapeutic Areas
Sponsors
Leads: National University of Singapore

This content was sourced from clinicaltrials.gov