• Aged ≥18 years and ≤75 years, regardless of gender.

• Documented history of primary hypertension.

• Stable use of at least two antihypertensive medications for a minimum of 4 consecutive weeks prior to randomization, specifically requiring a combination of an angiotensin II receptor blocker (ARB) and a calcium channel blocker (CCB) or a triple combination of ARB/CCB plus a diuretic agent . After at least 4 consecutive weeks of screening, blood pressure must meet the following criteria:

‣ Office systolic blood pressure (SBP) ≥150 mmHg and \<180 mmHg;

⁃ Office diastolic blood pressure (DBP) ≥90 mmHg;

⁃ 24-hour ambulatory systolic blood pressure ≥135 mmHg and \<170 mmHg.

• Patients who can understand the purpose of the trial, voluntarily participate and sign the informed consent form, and are willing to comply with clinical follow-up.