Accelerated 100Hz Magnetic Seizure Therapy for Psychotic Disorders
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This trial aims to evaluate the efficacy and safety of Magnetic Seizure Therapy (MST) as an augmentation of antipsychotic medications for psychosis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: f
View:
• (1) meets the diagnostic criteria for schizophrenia or other primary psychotic disorders according to DSM-5;
• (2) age range between 18 and 55 years;
• (3) Positive And Negative Syndrome Scale (PANSS) score≥60;
• (4) to provide informed consent.
Locations
Other Locations
China
Shanghai Mental Health Center
RECRUITING
Shanghai
Shanghai Mental Health Center
NOT_YET_RECRUITING
Shanghai
Contact Information
Primary
Jijun Wang, M.D, Ph.D
jijunwang27@163.com
86-21-34773065
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 50
Treatments
Experimental: Magnetic seizure therapy plus antipsychotics
The patients will receive antipsychotic drugs plus MST during the first 2 weeks.~A TwinCoil of MagPro XP will be positioned centrally over the frontal cortex in the midline position. The output power of MagPro XP is set to 100%, and stimulation frequency is 100 Hz. For MST titration, the first step is given at a 5-second train duration; if there is no seizure, the duration is increased to 10 seconds with a maximum limit of 10 seconds. The subsequent MST treatment will be maintained at 10 seconds. This procedure will be carried out under anesthesia.~A total of up to 10 treatments will be administered to participants, usually five times a week, for 2 weeks.
Active_comparator: antipsychotic drugs
The patients will receive second-generation antipsychotic drugs without MST or ECT during the first 2 weeks.
Related Therapeutic Areas
Sponsors
Leads: Shanghai Jiao Tong University School of Medicine