Skin Inflammation in Perimenopause: A Probiotic Intervention Proof of Concept Trial (SIPPI)
This study will explore whether a daily probiotic drink containing Lactobacillus casei Shirota (LcS) can help improve immune function and reduce inflammation in women going through perimenopause. Hormonal changes during this stage of life can affect the immune system, gut health, and skin, sometimes leading to increased inflammation or conditions such as acne. Participants will consume either a low-sugar LcS probiotic drink or a skimmed milk control drink every day for eight weeks. The study will assess markers of immune ageing, inflammation, skin health, wellbeing, and hormone levels. The results will help determine whether a safe, non-hormonal probiotic approach may support immune and skin health during perimenopause.
• Female, aged 40-50 years, in the perimenopausal transition (defined as menstrual cycle irregularity within the past 12 months but not yet 12 months of amenorrhoea).
• Clinician-diagnosed acne, defined as the presence of acne symptoms (e.g., comedones, papules, pustules, nodules) or a prior formal diagnosis of acne vulgaris by a healthcare professional.
• Willing and able to consume a daily oral intervention (2x 65 ml probiotic drinks or skimmed milk) for 8 weeks.
• Willing and able to provide sufficient blood, skin and stool samples at baseline and end-of-study (Week 8). Participants unable to provide adequate blood sample volumes will not be able to start the intervention.
• Willing and able to provide a photograph of the facial area, with all images anonymised for study purposes.
• Able to comply with study procedures, including attending clinic visits at KCL.
• Have access to a refrigerator at home and be able to store the study product(s) safely after collection (i.e., travel time allows safe storage).
• Capable of providing written informed consent.
• Have sufficient proficiency in English to complete study questionnaires and assessments.