Evaluating the Effectiveness of Platelet-Rich Plasma as an Adjunct to Fractional Carbon Dioxide Laser Therapy in Improving Facial Acne Scar Appearance: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart. The primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \< 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: f
View:

• Male and female participants

• Fitzpatrick skin types I to V

• Presence of moderate-to-severe acne scars

• Willing to undergo 3 treatment sessions and follow-up visits

• Able to provide informed consent -

Locations
Other Locations
Pakistan
Destrict Head Quarter Hospital, Gujranwala
RECRUITING
Gujranwala
Contact Information
Primary
YASAAN SAAQIB, MBBS
saani1992222@gmail.com
0923234525277
Backup
Nabeela Shahzadi
nabeela.pk82@gmail.com
+92 331 4218784
Time Frame
Start Date: 2025-10-31
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 70
Treatments
Experimental: Laser + PRP arm
Participants receive fractional CO₂ laser treatment followed by the application of autologous platelet-rich plasma (PRP). Three sessions are administered at four-week intervals. PRP is prepared using a double-spin centrifugation method and applied topically immediately after laser treatment.
Experimental: Laser only arm
Participants receive fractional CO₂ laser treatment alone, without PRP. Three sessions are administered at four-week intervals using the same laser parameters as the intervention group. To maintain masking, a placebo-filled syringe covered with opaque tape is touched to the skin without delivering PRP.
Related Therapeutic Areas
Sponsors
Leads: Gujranwala medical college District Headquarters Hospital, Gujranwala
Collaborators: Saglik Bilimleri Universitesi

This content was sourced from clinicaltrials.gov