Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
This is a randomized double blinded placebo-controlled study, conducted in Lund, Sweden. Patients will be randomized in two groups, with a ratio of 1:1. The experimental arm will receive intravenous Lidocaine perioperatively, and the Control arm will receive placebo, i.e. normal Saline. Postoperative both arms will get routine pain Control with PCA, Patient Controlled Analgesia with an intravenous Oxycodone-infusion. Outcome-measures will include patients pain intensity scoring, and opioid consumption.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age 18 yy
• Patient planned for minor hepatectomy
• Signed informed consent
Locations
Other Locations
Sweden
Skåne University Hospital of Lund
RECRUITING
Lund
Contact Information
Primary
Emil Östrand, MD
emil.ostrand@skane.se
+46-(0)46-171000
Backup
Bobby Tingstedt, Prof
bobby.tingstedt@skane.se
+46-(0)46-171000
Time Frame
Start Date: 2021-11-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 80
Treatments
Experimental: Lidocaine arm
The experimental arm will receive a bolus of 1,5mg/kg Lidocaine before induction of anesthesia, immediately followed by an infusion of 1,5mg/kg/h until 1 hour post surgery.
Placebo_comparator: Placebo arm
The placebo arm will receive the same amount of normal Saline.
Related Therapeutic Areas
Sponsors
Leads: Lund University Hospital