Role of Herpesviruses as a Causative Factor in Acute Apical Abscess
The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.
• Patient must be ≥ 18-year-old
• Patient must be systemically healthy; American Society of Anesthesiologists (ASA) Class I or II
• Patient must exhibit clinical evidence of pulp necrosis and acute apical abscess
• Patient must present with radiographic
• signs of apical disease either by
• periapical radiography or cone-beam
• computed tomography
• Patient consented to receive conventional pulpal debridement, incision and drainage at the end of the study
• Persistent pain of moderate or higher level (\>4) was the main inclusion criterion. Pain assessed as follows: 0 defined as no pain, 1-3 as mild pain, 4-6 as moderate pain, and 7-10 as severe pain