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Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 35
Healthy Volunteers: t
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• 18-35 years of age

• BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\]

• Not taking contraception or other types of medication that could influence reproductive status

• Regular menstruation

• Non-pregnant

• Medically free from chronic diseases

• Novel to downhill running

• Weight greater than or equal to 110 lbs

• Not taking exogenous hormones

• Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity

Locations
United States
California
Clinical Exercise Research Center
RECRUITING
Los Angeles
Contact Information
Primary
Todd Schroeder, PhD
eschroed@pt.usc.edu
3234422180
Time Frame
Start Date: 2025-03-07
Estimated Completion Date: 2026-08
Participants
Target number of participants: 30
Treatments
Experimental: Low estrogen; low progesterone
Participants will come in while on their period. During this time estrogen and progesterone concentrations are low.
Experimental: High estrogen; low progesterone
Participants will come in just before ovulation, when estrogen concentrations are high and progesterone concentrations remain low.
Experimental: Medium estrogen; high progesterone
Participants will come in just after ovulation when estrogen concentrations are at a medium level, and progesterone concentrations are high.
Related Therapeutic Areas
Sponsors
Leads: University of Southern California

This content was sourced from clinicaltrials.gov