The Effect of Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - The TRADR Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;
• Aged 18 or older;
• Provision of informed consent;
• Cognitive ability and English-language skills required to complete outcome measures.
Locations
Other Locations
Canada
Toronto Western Hospital
RECRUITING
Toronto
Contact Information
Primary
Ryan Paul
jhanna.bermudez@uhn.ca
416-603-5839
Time Frame
Start Date: 2025-08-13
Estimated Completion Date: 2027-12
Participants
Target number of participants: 90
Treatments
Experimental: Topical TRanexamic Acid
10mL of 100mg/mL TXA in addition to the standard care
Placebo_comparator: Placebo
10mL of 100mg/mL normal saline in addition to the standard care
Related Therapeutic Areas
Sponsors
Leads: University Health Network, Toronto