Acute Pain Clinical Trials

Find Acute Pain Clinical Trials Near You

The Significance of Physical Activity for Insulin Signaling Dynamics and Insulin Sensitivity

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. Furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity. This will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 22
Maximum Age: 35
Healthy Volunteers: t
View:

• Healthy individuals (no known diseases)

• No use of medication

• Non-smokers

• Male

• Aged 22-35 years

• Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg

• BMI between 28 and 35

Locations
Other Locations
Denmark
University of Copenhagen, August Krogh Section for Human and Molecular Physiology
RECRUITING
Copenhagen
Contact Information
Primary
Jørgen FP Wojtaszewski, Professor
jw@nexs.ku.dk
+4535321625
Backup
Nicolai S Henriksen, MSc
nsh@nexs.ku.dk
+4560110222
Time Frame
Start Date: 2025-05-05
Estimated Completion Date: 2027-01
Participants
Target number of participants: 8
Treatments
Experimental: Post-exercise insulin sensitivity
Young healthy males will perform a single bout of knee-extensor exercise and insulin action is investigated 4 hours after cessation of exercise. Insulin action towards muscle glucose uptake will be investigated during a 120 min euglycemic hyperinsulinemic clamp.
Related Therapeutic Areas
Sponsors
Leads: University of Copenhagen

This content was sourced from clinicaltrials.gov