The Significance of Physical Activity for Insulin Signaling Dynamics and Insulin Sensitivity
The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. Furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity. This will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.
• Healthy individuals (no known diseases)
• No use of medication
• Non-smokers
• Male
• Aged 22-35 years
• Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg
• BMI between 28 and 35