A Pilot Randomized Controlled Trial Assessing Pain and Opioid Outcomes Among Patients Undergoing Total Knee Arthroplasty Receiving 5-Day Outpatient Adductor Canal Continuous Versus Single Injection Blocks
Status: Recruiting
Location: See location...
Intervention Type: Drug, Device
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult participants of at least 18 years of age
• Undergoing a primary, unilateral, total knee arthroplasty
• Planned single-injection adductor canal nerve block
• Weight \> 50 kg (to minimize the risk of local anesthetic toxicity)
Locations
United States
California
University of California, San Diego
RECRUITING
La Jolla
Contact Information
Primary
Rodney A Gabriel, MD
ragabriel@health.ucsd.edu
858-663-7747
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 40
Treatments
Experimental: Continuous adductor canal block
single injection with ropivacaine (0.5%) of the adductor canal block and a 5-day continuous perineural infusion of ropivacaine (0.2%) (experimental group)
Active_comparator: single injection adductor canal block
single injection with ropivacaine (0.5%) of the adductor canal block and no continuous nerve block added
Related Therapeutic Areas
Sponsors
Leads: University of California, San Diego