Efficacy of Methylprednisolone for Pain Control After ACL Repair: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 13
Maximum Age: 50
Healthy Volunteers: f
View:

• Patient undergoing ACL repair or ACL reconstruction with tendon autograft

• Age 13-50 years old

• Able to provide informed consent or parent/legal guardian is able for minors

Locations
United States
Missouri
Saint Louis University
RECRUITING
St Louis
Contact Information
Primary
Scott Kaar
scott.kaar@ssmhealth.com
314-617-3405
Backup
Allison Gruender
allison.gruender@health.slu.edu
314-617-3406
Time Frame
Start Date: 2025-10
Estimated Completion Date: 2031-09
Participants
Target number of participants: 90
Treatments
Active_comparator: Medrol group
Patients will receive Medrol dose pack, Meloxicam, Hydrocodone/Acetaminophen, and Gabapentin as pain regimen upon discharge from surgery.
Active_comparator: No Medrol group
Patients will receive Ketorolac, Hydrocodone/Acetaminophen, and Gabapentin as pain regimen upon discharge from surgery.
Related Therapeutic Areas
Sponsors
Leads: St. Louis University

This content was sourced from clinicaltrials.gov