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Treatment Validation of an Ultrasound Imaging Biomarker for Myofascial Pain

Status: Recruiting
Location: See location...
Intervention Type: Device, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to see if a body test called the NUN biomarker can track changes in chronic low back pain after dry needling and predict who will feel better. This study is for adults with chronic low back pain from muscle pain (Myofacial Pain). The main questions are: * Does the biomarker drop when pain improves? * Can it predict who benefits most? * Do higher starting levels mean better results with real dry needling? Investigators will compare real and fake (sham) dry needling using ultrasound, muscle pressure tests, and pain reports before and after treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 70
Healthy Volunteers: f
View:

• Ages 20-70;

• Predominantly axial LBP (meeting NIH definition of cLBP with daily pain for at least 3 months) with a MP component as determined by the standardized examination for MP;

• Average pain score of \> 3/10, with low back pain being the primary pain site;

• CLBP meeting Quebec Task Force Classification System categories I-III (from axial pain only to pain radiating beyond the knee without neurological signs). Constant radicular pain associated with sensory loss is likely a confounder to dry needling treatment success;

• NO HISTORY of receiving dry needling, to improve the effectiveness of the blind;

• Demonstration of healthcare seeking at some point for LBP.

Locations
United States
Pennsylvania
Kauffman Medical Building
RECRUITING
Pittsburgh
Contact Information
Primary
Ajay Wasan, MD, MSc
wasanad@upmc.edu
412-665-8048
Backup
Kunal Lohana, MPH
kul31@pitt.edu
412-648-4925
Time Frame
Start Date: 2025-10-06
Estimated Completion Date: 2027-08-31
Participants
Target number of participants: 80
Treatments
Active_comparator: Dry needling
Sham_comparator: Sham Dry Needling
Related Therapeutic Areas
Sponsors
Collaborators: National Center for Complementary and Integrative Health (NCCIH)
Leads: Ajay Wasan, MD, Msc

This content was sourced from clinicaltrials.gov