Evaluation of N-acetylcysteine as an Intracanal and Adjunctive Systemic Medication in Root Canal Treatment of Necrotic Mature Teeth With Apical Periodontitis: a Randomized Controlled Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Maximum Age: 60
Healthy Volunteers: f
View:
• Mature necrotic teeth.
• Radiographic evidence of periapical bone loss.
• Teeth that require primary endodontic treatment.
• Restorable teeth.
Locations
Other Locations
Egypt
Faculty of Dentistry, Alexandria University
RECRUITING
Alexandria
Contact Information
Primary
Mai M Hussein, MSc (Endo)
mai.hussein.dent@alexu.edu.eg
01140556563
Backup
Mahmoud R Aboelseoud, PhD (Endo)
mahmoud.aboelseoud@alexu.edu.eg
01222345986
Time Frame
Start Date: 2025-11-15
Estimated Completion Date: 2026-06
Participants
Target number of participants: 40
Treatments
Active_comparator: Calcium hydroxide (Ca(OH)₂)
UltraCal XS calcium hydroxide (Ca(OH)₂) intracanal medication for 7 days
Experimental: N-acetylcysteine (NAC)
N-acetylcysteine (NAC) intracanal medication for 7 days and 600 mg/day oral NAC for 21 days
Related Therapeutic Areas
Sponsors
Leads: Alexandria University