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Comparison of Deep Subgluteal Block and Pericapsular Nerve Group Block Combined With Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia After Hip Arthroplasty: A Randomized Prospective Study

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized, prospective study aims to compare the clinical efficacy of ultrasound-guided Deep Subgluteal Block (DSGB) versus Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve (LFCN) block for postoperative analgesia management in patients undergoing hip arthroplasty. A total of 60 patients scheduled for hip arthroplasty under general anesthesia will be randomly allocated into two equal groups of 30: Group DSG and Group PENG+LFCN. Total local anesthetic volume (30 mL) and active drug dose (75 mg bupivacaine) will be standardized across both groups to ensure rigorous blinding and high methodological quality. The primary outcome of the study is to compare total postoperative opioid (fentanyl) consumption within the first 24 hours. Secondary outcomes include postoperative pain scores evaluated via the Numerical Rating Scale (NRS) at rest and during movement, the presence and degree of quadriceps motor block, and opioid-related adverse effects (e.g., nausea, vomiting, pruritus).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Patients scheduled for elective total or partial hip arthroplasty under general anesthesia

• American Society of Anesthesiologists (ASA) physical status I-III

• Aged between 18 and 80 years

• Able to understand the study procedures, give voluntary written informed consent, and operate a patient-controlled analgesia (PCA) device

Locations
Other Locations
Turkey
Medipol Mega University Hospital
RECRUITING
Istanbul
Contact Information
Primary
Yunus O Atalay, MD, Prof., DESAIC
yoatalay@medipol.edu.tr
+90 212 453 4800
Time Frame
Start Date: 2026-08-01
Estimated Completion Date: 2027-01-30
Participants
Target number of participants: 60
Treatments
Active_comparator: Group DSG
Patients will receive an ultrasound-guided Deep Subgluteal Block using a total of 30 mL of 0.25% bupivacaine (15 mL administered beneath the gluteus minimus muscle and 15 mL beneath the gluteus medius muscle).
Active_comparator: Group PENG+LCFN
Patients will receive an ultrasound-guided Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block. The PENG block will be performed with 20 mL of 0.25% bupivacaine. The LFCN block will be performed using a 10 mL volume consisting of 5 mL of 0.25% bupivacaine diluted with 5 mL of normal saline (0.9% NaCl), resulting in a final local anesthetic concentration of 0.125% bupivacaine at the LFCN site.
Related Therapeutic Areas
Sponsors
Leads: Medipol University

This content was sourced from clinicaltrials.gov

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