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Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery

Status: Recruiting

Location: See location...

Intervention Type: Drug, Biological

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Healthy Volunteers: t

View:

• Patients aged 18 years and older.

• Patients with good general health

• Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable)

• Patients willing and able to attend all postoperative follow-up visits

Locations

Other Locations

Cyprus

Final International University Faculty of Dentistry

RECRUITING

Nicosia

Contact Information

Primary

Meliz Kneebone, DDS

meliz-95@hotmail.com

+905338425731

Time Frame

Start Date: 2024-09-03

Estimated Completion Date: 2026-08

Participants

Target number of participants: 60

Treatments

Active_comparator: Standard Postoperative Treatment (Control)

Participants receive standard postoperative treatment following impacted mandibular third molar surgery, including amoxicillin/clavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash. No platelet-rich fibrin (PRF) or corticosteroid is administered.

Experimental: Platelet-Rich Fibrin (PRF)

Participants receive platelet-rich fibrin (PRF) placed into the extraction socket in addition to standard postoperative treatment consisting of amoxicillin/clavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash following impacted mandibular third molar surgery.

Experimental: Platelet-Rich Fibrin Plus Corticosteroid

Participants receive platelet-rich fibrin (PRF) placement into the extraction socket followed by intramuscular corticosteroid administration, in addition to standard postoperative treatment consisting of amoxicillin/clavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash following impacted mandibular third molar surgery.

Related Therapeutic Areas

Acute Pain

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