Clinical Efficacy of A-PRF With Hyaluronic Acid in Enhancing Bone Formation in Dental Implantation
This randomized parallel-group clinical trial aimed to evaluate the clinical efficacy of advanced platelet-rich fibrin (A-PRF) combined with hyaluronic acid (HA) in enhancing peri-implant bone formation in patients undergoing delayed dental implant placement. Participants will be allocated to either a test group, in which A-PRF combined with HA is applied at the implant site, or a control group receiving conventional implant placement without adjunctive biomaterials. Peri-implant bone changes will be assessed using cone-beam computed tomography (CBCT), including radiographic bone density and bone volume measurements. Implant stability will also be evaluated using resonance frequency analysis at the time of implant placement and during follow-up. Additional clinical outcomes include postoperative pain and implant survival. The participants will be followed up for six months after implant placement.
• \- Adults aged 18-65 years.
• Patients requiring delayed dental implant placement in a posterior mandibular edentulous site
• Sufficient residual alveolar bone height and width to permit conventional implant placement without the need for simultaneous guided bone regeneration (GBR), ridge augmentation, or other bone-grafting procedures.
• Good general health or a medically controlled and stable systemic condition compatible with elective implant surgery and not expected to materially compromise wound or bone healing.
• Non-smokers with no current use of tobacco products.
• Acceptable oral hygiene and a periodontal condition compatible with implant surgery following any required professional treatment and reassessment.
• Ability and willingness to undergo the required clinical and radiographic assessments, including CBCT examinations at baseline and at the 6-month follow-up.
• Ability and willingness to attend the scheduled follow-up visits and comply with the study procedures.
• Provision of written informed consent before study participation.