The Contribution of the Combination of Transthoracic and Transcranial Ultrasonography to the Titration of Positive End-expiratory Pressure in Patients With Acute Respiratory Distress Syndrome and Acute Brain Injury
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥ 18 years
• Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)
• Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission
Locations
Other Locations
Greece
George Papanikolaou General Hospital
RECRUITING
Thessaloniki
Contact Information
Primary
Theodoros Schizodimos, MD
teoschizo@gmail.com
+306973439717
Backup
Georgia Pitsiou, PhD
gpitsiou@yahoo.gr
Time Frame
Start Date: 2025-12-01
Estimated Completion Date: 2027-07
Participants
Target number of participants: 30
Treatments
Experimental: Stepwise PEEP Elevation Protocol Arm
All participants with ARDS and ABI will undergo a protocolized stepwise increase of PEEP at four levels. Each participant will serve as their own control.
Related Therapeutic Areas
Sponsors
Leads: Theodoros Schizodimos