Effect of PEEP on Ventilartion/Perfusion Ratios According to Different Phenotypes in Patients With ARDS (France)
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation/perfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O)
• undergoing deep sedation
• on controlled mechanical ventilation
• between 24 hours and 5 days after intubation.
Locations
Other Locations
France
Angers Hospital
RECRUITING
Angers
Contact Information
Primary
François Beloncle, MD
francois.Francois.Beloncle@chu-angers.fr
+33 241 35 58 65
Backup
UH Angers DRCI
DRCI-Promotion-Interne@chu-angers.fr
+33 2 41 35 54 96
Time Frame
Start Date: 2024-02-08
Estimated Completion Date: 2026-09
Participants
Target number of participants: 50
Treatments
Experimental: Strategy A: PEEP 15 cmH2O → PEEP 5 cmH2O
Active_comparator: Strategy B: PEEP 5 cmH2O → PEEP 15 cmH2O
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Angers