Find Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Near You
The Role of CXCR4-expressing Neutrophils in Influenza-related Acute Respiratory Distress Syndrome
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
Influenza is still responsible for more than 650,000 deaths per year worldwide and no major improvements in patients' care has been made despite 50 years of research. Especially, there is no therapeutic strategy targeting the dysregulated host response. CXCR4-expressing neutrophils seem to be involved in the rupture of host resistance. The aim of this study is thus to compare the percentage of blood CXCR4-expressing neutrophils between influenza survivors and non-survivors.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patient aged 18 yo or above.
• Acute respiratory distress syndrome as defined by the Berlin classification.
• Invasive mechanical ventilation for less than 24 hours.
• Cause of ARDS:
‣ Influenza infection proven by polymerase chain reaction OR
⁃ Bacterial infection (tracheal aspirate with more than 105 CFU/mL and BAL with more than 104 CFU/mL.
⁃ Pancreatitis according to the 2013 Working Group IAP/APA Acute Pancreatitis Guidelines.
⁃ Peritonitis according to the 2018 SFAR guidelines.
• Health insurance.
• Written informed consent from legal relative or representative.
Locations
Other Locations
France
Hopital Pellegrin
RECRUITING
Bordeaux
Hopital Haut-Lévêque
NOT_YET_RECRUITING
Pessac
Contact Information
Primary
Renaud PREVEL, Dr
renaud.prevel@u-bordeaux.fr
5 57 87 26 26
Time Frame
Start Date:2024-12
Estimated Completion Date:2026-12
Participants
Target number of participants:90
Treatments
Influenza-related ARDS group
Person with influenza virus infection proven by a positive polymerase chain reaction test for the influenza ARDS group. Additional tubes taken when blood is drawn during treatment, and bronchoalveolar fluid sample.
Bacterial-related ARDS group
A person with a proven bacterial infection (105 colony-forming units/mL for tracheal aspirates and more than 104 colony-forming units/mL for BAL). Additional tubes taken when blood is drawn during treatment, and bronchoalveolar fluid sample.
Extra-pulmonary (digestive inflammation) ARDS group
Person presenting with acute pancreatitis according to the 2013 international recommendations (typical pain, lipasemia above 3 times normal and/or abnormality on imaging).~Or Person presenting with acute bacterial peritonitis based on a clinical diagnosis and bacteria isolated on peritoneal samples (RFE SFAR 2018). Additional tubes taken when blood is drawn during treatment, and bronchoalveolar fluid sample.