Acute Respiratory Distress Syndrome (ARDS) Clinical Trials

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Incidence of Complications From the Alveolar Opening Maneuver in Mechanically Ventilated Children With Respiratory Distress Syndrome

Status: Recruiting

Location: See location...

Intervention Type: Procedure

Study Type: Observational

SUMMARY

The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric patients with acute respiratory distress syndrome (ARDS). These procedures are part of the standard care provided in the Pediatric Intensive Care Unit (PICU) and are used to improve pulmonary oxygenation and respiratory mechanics. Through this study, we aim to gather information that will help improve the safety and effectiveness of these interventions in critically ill patients.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 1 month

Maximum Age: 14

Healthy Volunteers: f

View:

• Patients under 14 years of age admitted to the HCANK PICU

• More than 4 hours of invasive mechanical ventilation (IMV)

• An oxygenation index (OI) ≥4 or an oxygen saturation index (OSI) ≥5

• Indication for ARM and PEEP as determined by the treating team

Locations

Other Locations

Argentina

Hospital Cuenca Alta Néstor Kirchner

RECRUITING

Canuelas

Contact Information

Primary

Maria Belén B castelli, BCS

investigacion@hospitalcuencaalta.org.ar

+54 2227442582

Time Frame

Start Date: 2025-08-18

Estimated Completion Date: 2026-08

Participants

Target number of participants: 143

Treatments

Alveolar Opening Maneuver and PEEP Titration (AOM+P)

Patients under invasive mechanical ventilation for pediatric acute respiratory distress syndrome (PARDS) who undergo a standardized alveolar opening maneuver followed by decremental PEEP titration according to institutional protocol. The maneuver consists of stepwise increases in PEEP until reaching a plateau pressure of 35 cmH₂O (or up to 40 cmH₂O in patients with reduced chest wall compliance), maintained for 2 minutes, followed by decremental PEEP titration to determine the optimal level based on driving pressure and oxygen saturation. The procedure is performed once clinically indicated, with continuous hemodynamic and oxygenation monitoring.

Related Therapeutic Areas

Acute Respiratory Distress Syndrome (ARDS)

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