Impact of Trunk Inclination on Lung Mechanics According to PEEP and Reruitability
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio \<= 200 mmHg)
• Under continuous sedation with or without paralysis
Locations
Other Locations
China
West China Hospital of Sichuan University
NOT_YET_RECRUITING
Chengdu
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
RECRUITING
Jinan
Zhongda Hospital, Southeast University
RECRUITING
Nanjing
Contact Information
Primary
Fengmei Guo, M.D
fmguo2022@163.com
+8618255127433
Time Frame
Start Date: 2026-03-20
Estimated Completion Date: 2027-04-30
Participants
Target number of participants: 40
Treatments
Intubated mechanically ventilated ARDS patients
Intubated mechanically ventilated patients with moderate to severe ARDS according to the Berlin definition
Related Therapeutic Areas
Sponsors
Leads: Zhongda Hospital