Study for Reference Intervals and Optimal Cut-offs for Salivary Cortisol
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The goal of this observational study is to establish the normal reference intervals of salivary cortisol and optimal cut-offs for Cushing's sydrome and adrenal insufficiency.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:
• Age ≥ 18 and ≤ 60 years old;
• Body mass index (BMI) ≥ 18.5 and ≤ 24.9 kg\*m\^-2;
• No previous history of chronic diseases such as hyperglycemia, hypertension, dyslipidemia, coronary heart disease and stroke;
• Normal glucose regulation, defined as: fasting blood-glucose \< 5.6 mmol/L, 2-hour blood-glucose after glucose load \< 7.8 mmol/L, and glycated hemoglobin (HbA1c) \< 5.7%.
• Aged 18 to 80 years old;
• Patients with suspected Cushing's syndrome or adrenal insufficiency.
Locations
Other Locations
China
Shanghai Sixth People's Hospital
RECRUITING
Shanghai
Contact Information
Primary
Jian Zhou, Doctor
zhoujian@sjtu.edu.cn
+86-021-64369181
Time Frame
Start Date: 2025-09-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 220
Treatments
Heathy Volunteers
120 Healthy Volunteers for the establishment of reference intervals of salivary cortisol
Cushing's sydrome
50 cases diagnosed with Cushing's sydrome
Adrenal insufficiency
50 cases diagnosed with adrenal insufficiency
Related Therapeutic Areas
Sponsors
Leads: Shanghai 6th People's Hospital