The Regulatory Mechanism of EGR2 Mediated by miR-150-5p on Allergic Rhinitis
Status: Unknown
Location: See location...
Intervention Type: Genetic
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
EGR2 may be a target for the treatment of nasal polyps.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Maximum Age: 76
Healthy Volunteers: f
View:
• All patients were stopped by systemic or topical corticosteroid treatment at least one month before the study.
Locations
Other Locations
China
Department of Central Laboratory of the Third Affiliated Hospital of ZunYi Medical University
Zunyi
Time Frame
Start Date: 2023-01-30
Completion Date: 2023-05-05
Participants
Target number of participants: 3
Treatments
Experimental: immunohistochemistry
Thirty-eight patients with confirmed nasal polyps (20 with primary CRSwNP and allergic rhinitis (AR) and 18 with CRSWNP) and 20 patients with chronic hypertrophic rhinitis were included. The nasal polyps and mucosal specimens of all patients were collected and analyzed by immunohistochemistry
Experimental: WestBlot
Thirty-eight patients with confirmed nasal polyps (20 with primary CRSwNP and allergic rhinitis (AR) and 18 with CRSWNP) and 20 patients with chronic hypertrophic rhinitis were included. The nasal polyps and mucosal specimens of all patients were collected and analyzed by Western Blot.
Related Therapeutic Areas
Sponsors
Leads: Zu-xia Ma