Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 90
Healthy Volunteers: f
View:

• Amnestic MCI or Mild Alzheimer's diagnosis

• Age 50-90

• English-speaking

• Ability to provide informed consent

• Normal or corrected-to-normal hearing and vision

Locations
United States
California
UCLA Semel Institute for Neuroscience and Behavior
RECRUITING
Los Angeles
Contact Information
Primary
Natalie Rotstein
tfus@mednet.ucla.edu
‭(310) 794-0077‬
Backup
Sabrina Halavi
tfus@mednet.ucla.edu
‭(310) 794-0077‬
Time Frame
Start Date: 2022-09-01
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 144
Treatments
Active_comparator: LIFUP Dose Group 1
Administration of low intensity focused ultrasound (LIFUP) dose level 1 to the entorhinal cortex.
Active_comparator: LIFUP Dose Group 2
Administration of low intensity focused ultrasound (LIFUP) dose level 2 to the entorhinal cortex.
Active_comparator: LIFUP Dose Group 3
Administration of low intensity focused ultrasound (LIFUP) dose level 3 to the entorhinal cortex.
Sham_comparator: Sham LIFUP
No administration of LIFUP. The device will be affixed to the user's head but not turned on.~Additionally, if at the end of the study, the treatment has been shown to be effective, placebo subjects will be offered a free session using the optimally effective dose, if they consented to being contacted for this purpose.
Sponsors
Leads: University of California, Los Angeles
Collaborators: National Institute on Aging (NIA)

This content was sourced from clinicaltrials.gov

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