Targeting Cognitive Control to Improve Physical Activity Adherence in Midlife for Alzheimer's Risk Reduction

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle. The main questions it aims to answer are: * Can cognitive training designed to improve cognitive control improve physical activity adherence? * What are the psychological, physiological, cognitive, and sociodemographic factors that affect the impact of cognitive control on physical activity adherence? Participants will * Complete a 6-week home-based, computerized cognitive training program * Complete a 6-week home-based, aerobic exercise training program with supervision of a health coach and trainer * Complete a 6-week home-based, aerobic exercise training program prescribed by a health coach and trainer * Visit the laboratory before and after cognitive training, and before and after physical training, to complete assessments of cognition and aerobic fitness

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 65
Healthy Volunteers: t
View:

• Between the ages of 40 and 65 years old

• Full-time working status of an average of 35 hrs./week or more

• Scoring as Low Active by the short form of the International Physical Activity Questionnaire (IPAQ)

• Eligible to participate in an aerobic exercise intervention based on the Physical Activity Readiness Questionnaire

• Approval from their Primary Care Physician for approval to participate in the prescribed training program

• Corrected vision of 20/40

• Fluent in English to ensure instructions for cognitive assessments and training are understood clearly

Locations
United States
Iowa
Psychological and Brain Sciences Building
RECRUITING
Iowa City
Massachusetts
Center for Cognitive and Brain Health
RECRUITING
Boston
Contact Information
Primary
Michelle W Voss, PhD
michelle-voss@uiowa.edu
319-335-2057
Backup
Charles Hillman, PhD
c.hillman@northeastern.edu
617.373.8342
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2027-11-30
Participants
Target number of participants: 264
Treatments
Experimental: Cognitive Control: Neutral (CC-N)
Game-like cognitive training program that they will run themselves at home up to 5 times per week. A game-like experience begins, where the participant is encouraged to earn points and in-game rewards to advance. In this condition, all the stimuli presented are neutral (not emotionally valenced). After each session, the difficulty of the next session is updated.
Experimental: Cognitive Control: Emotionally Valenced (CC-E)
Game-like cognitive training program that they will run themselves at home up to 5 times per week. A game-like experience begins, where the participant is encouraged to earn points and in-game rewards to advance. In this condition, all the stimuli presented within the tasks are emotionally valenced.
Active_comparator: Casual Games
Composed of 6 commercially available computer games. It matches the experimental treatment program in overall program use intensity, time-spent attending, delivered rewards, and overall engagement.
Related Therapeutic Areas
Sponsors
Leads: University of Iowa
Collaborators: National Institute on Aging (NIA), Northeastern University

This content was sourced from clinicaltrials.gov