Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Mini Mental State Examination (MMSE) score \< 25

Locations
United States
Louisiana
Pennington Biomedical Research Center
RECRUITING
Baton Rouge
Contact Information
Primary
Tim Gilbert, M.D.
Tim.Gilbert@pbrc.edu
2257632584
Backup
Candida Rebello, Ph.D.
Candida.Rebello@pbrc.edu
2257633159
Time Frame
Start Date: 2025-12
Estimated Completion Date: 2027-05
Participants
Target number of participants: 8
Treatments
Experimental: Physiologic Insulin
Insulin infusion at five-minute intervals over approximately two hours weekly for six months. Initially infusion will be weekly and then frequency will reduce based on participants' response.
Related Therapeutic Areas
Sponsors
Leads: Pennington Biomedical Research Center

This content was sourced from clinicaltrials.gov