Spectacle Correction for the Treatment of Amblyopia

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Amblyopia is a developmental anomaly resulting from abnormal visual experiences in early life. Amblyopia causes reduced visual acuity in the absence of a pathology. Adult sensory systems are believed to be structurally invariant beyond early, critical periods of development. However, recent evidence suggest that visual functions in adults with amblyopia can be improved with optical correction alone. This study aims to investigate whether improvements in best corrected visual acuity and other visual functions can result following appropriate optical correction in adults with amblyopia. Functional measures relating to vision, binocular vision, and eye movements will be used to assess the efficacy of refractive correction for improving vision. This study will help us better understand the improvements in visual functions following optical correction, as well as the mechanisms underlying neuroplasticity in adults with amblyopia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 39
Healthy Volunteers: t
View:

• 18-39 (inclusive) years of age

• Anisometropic amblyopia (difference of ≥0.50D spherical equivalent or ≥1.50D astigmatism between eyes) or mixed mechanism amblyopia (strabismus and anisometropia)

• Best corrected visual acuity (BCVA) in the amblyopic eye of 0.3 logMAR to 1.0 logMAR (inclusive)

• BCVA in the non-amblyopic eye of 0.1 logMAR or better, and an interocular VA difference of 2 logMAR lines or more

• Difference of 1.00D or more between current refractive correction and study prescription

• Good general health

Locations
Other Locations
Canada
University of Waterloo
RECRUITING
Waterloo
Hong Kong Special Administrative Region
Centre for Eye and Vision Research Limited
RECRUITING
Hong Kong
Contact Information
Primary
Benjamin Thompson, PhD
ben.thompson@cevr.hk
+852-3169-9631
Backup
Ken WS Tan, PhD
ken.tan@cevr.hk
+852-3169-9631
Time Frame
Start Date: 2022-06-13
Estimated Completion Date: 2027-05-31
Participants
Target number of participants: 36
Treatments
Experimental: Optical correction
Prescription of spectacles for full-time wear to correct refractive error
Authors
Nianzeng Zhong
Related Therapeutic Areas
Sponsors
Collaborators: The Hong Kong Polytechnic University, University of Waterloo
Leads: Centre for Eye and Vision Research

This content was sourced from clinicaltrials.gov