ReRad III. Pencil Beam Proton Therapy for Recurrences in Anal Cancer Patients Previously Treated With Radiotherapy
Who is this study for? Patients with Anal Canal Cancer
What treatments are being studied? Pencil Beam Proton Therapy
Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This protocol aims to determine toxicity and efficacy of re-irradiation for patients with recurrences from anal cancers with dose-escalated pencil beam proton therapy either pre-operative for marginally resectable recurrences or as a definitive treatment strategy (un-resectable, operation declined etc.). The over-all aim is to improve local tumor control with acceptable side effects.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Recurrent anal cancer
• Bioptically verified (squamous cell carcinoma)
• Available dose plan from primary radiotherapy
• Previous RT (\>30Gy EQD2)
• Evaluated in MDT-conferences (Herlev, Aarhus)
• Age\>18 years
• PS 0-2
• Adequate organ function
• Written informed consent
Locations
Other Locations
Denmark
Danish Centre for Particle Therapy
RECRUITING
Aarhus N
Contact Information
Primary
Camilla Kronborg, MD, PhD
camkro@rm.dk
+45 78 45 00 00
Time Frame
Start Date: 2021-07-07
Estimated Completion Date: 2030-07-06
Participants
Target number of participants: 55
Treatments
Experimental: Doseescalated pencil beam proton therapy
Neo-adjuvant or definitive pencil beam proton therapy: 55 Gy(RBE)/44fx - 65 Gy(RBE)/52 fx (1.25 Gy per fraction), two fractions a day.
Related Therapeutic Areas
Sponsors
Leads: University of Aarhus