Jack Jumper Ant Venom Immunotherapy Long-term Effectiveness Investigation

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Jack Jumper ant (JJA) venom allergy is a uniquely Australian medical condition. It is the leading cause of venom allergy and affects up to three per cent of the population. 70 percent of people with JJA allergy will have another reaction on a repeat sting and this sensitivity appears to persist for many years. Venom immunotherapy (VIT) has been shown to be a safe and effective treatment in the prevention of severe systemic allergic reactions (anaphylaxis) to future stings. It is currently offered to patients as standard care in Tasmania, South Australia and Victoria. However, whilst JJA VIT has been used for many years, there is a lack of evidence on the long-term benefit of the treatment and how it impacts patient quality of life. This trial will offer patients who have completed a JJA VIT program (between 3 and \< 6-years duration) and have been off-treatment for at least 18-months and \< 5 years, to have a supervised JJA sting challenge and blood test to assess their JJA venom tolerance level. It will also ask them to complete a set of questionnaires at different timepoints to obtain a history of their exposure and reactions to JJA stings outside of the hospital setting (field stings), and to measure the impact of the completed VIT and knowledge of their sting challenge outcome on their quality of life and their behaviours around auto-injectors. These measures will be used to explore the long-term effectiveness of JJA VIT and the impact of a sting challenge post VIT on a patient's quality of life.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Completed a continuous program of JJA VIT of between 3 and \< 6 years duration.

• Have ceased JJA VIT for ≥ 18 months but \< 5 years.

• Have the ability to provide informed consent.

Locations
Other Locations
Australia
Royal Adelaide Hospital
NOT_YET_RECRUITING
Adelaide
Monash Medical Centre
NOT_YET_RECRUITING
Clayton
Royal Hobart Hospital
RECRUITING
Hobart
Contact Information
Primary
National Allergy Centre of Excellence
nace@mcri.edu.au
61 3 99366752
Time Frame
Start Date: 2025-11-25
Estimated Completion Date: 2029-10
Participants
Target number of participants: 100
Treatments
Experimental: Participants who have completed Jack Jumper Ant Venom Immmunotherapy treatment
Related Therapeutic Areas
Sponsors
Leads: Murdoch Childrens Research Institute

This content was sourced from clinicaltrials.gov