The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of midazolam, ketamine and ondansetron. These drugs are FDA approved and commonly used before, during and after surgical procedures.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Not have a history of an adverse reactions to midazolam, ketamine or ondansetron
• Ability to understand study procedures and to comply with them for the entire length of the study.
• Contraception is not necessary, and we will include women of reproductive capability.
Locations
United States
Arizona
Mayo Clinic Arizona
RECRUITING
Scottsdale
Time Frame
Start Date: 2025-11-05
Estimated Completion Date: 2026-10-30
Participants
Target number of participants: 60
Treatments
Experimental: Study Group
Study team is developing a new diagnostic skin testing procedure to determine non-irritant concentrations of midazolam, ketamine and ondansetron administered to patients before, during or after surgery.
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic
Collaborators: Arizona Biomedical Research Commission (ABRC)