Oxygen Consumption, Early Postoperative Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass: a Prospective Observational Study

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. The study focuses on patients over 18 years old who are having planned heart surgery with a heart-lung machine (cardiopulmonary bypass). The main questions the study aims to answer are: 1. How does oxygen consumption in the early hours after surgery relate to lactate levels (a sign of low oxygen supply to the tissues)? 2. How is oxygen consumption linked to signs of poor blood flow and organ injury (such as heart, kidney, liver, brain, and gut damage)? Researchers will measure oxygen consumption after surgery using a technique called indirect calorimetry. They will also track blood flow and oxygen use during surgery and check for signs of organ injury the day after the procedure. The study will include 65 participants. People with certain health conditions, like severe anemia, high lactate levels before surgery, or needing intensive care or extra oxygen supply before surgery, will not be included. By understanding how oxygen consumption relates to blood flow and organ injury, this research may help to better manage patients after heart surgery and reduce complications.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Elective cardiac surgery requiring cardiopulmonary bypass

Locations
Other Locations
Sweden
Uppsala University Hospital
RECRUITING
Uppsala
Contact Information
Primary
Julia Jakobsson MD PhD
julia.o.jakobsson@akademiska.se
+46-18-610 00 00
Backup
Olle Lönnemark MD
olle.lonnemark@akademiska.se
+46 -18-610 00 00
Time Frame
Start Date: 2025-05-05
Estimated Completion Date: 2026-02
Participants
Target number of participants: 65
Related Therapeutic Areas
Sponsors
Leads: Uppsala University Hospital

This content was sourced from clinicaltrials.gov