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Carbetocin Administration for the Prevention of Postpartum Hemorrhage in Twin Deliveries: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies. Heavy bleeding after delivery, also called postpartum hemorrhage, is more common after twin births and can lead to anemia, blood transfusions, and other serious health problems. In this study, bleeding will be evaluated by measuring how much blood hemoglobin levels drop from before delivery to the day after delivery. The main questions this study aims to answer are: * Does giving carbetocin after delivery lower blood loss compared with standard oxytocin treatment? * Is carbetocin safe and practical to use in twin deliveries? Researchers will compare carbetocin to standard oxytocin treatment to see which approach better prevents bleeding after twin vaginal or cesarean delivery. Participants will: * Be randomly assigned to receive either carbetocin or standard oxytocin after the second twin is delivered * Have blood tests before delivery and on the day after delivery * Be followed during their hospital stay and for up to six weeks after delivery for safety outcomes

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Pregnant individuals aged ≥18 years

• Twin pregnancies

• Gestational age ≥23 weeks

Locations
Other Locations
Israel
Sheba Medical Center
RECRUITING
Ramat Gan
Contact Information
Primary
Avihu Krieger, MD
avihuey@gmail.com
+972547421909
Backup
Tal Cahan, MD
Tal.Cahan@sheba.health.gov.il
+972528305662
Time Frame
Start Date: 2026-05-05
Estimated Completion Date: 2028-12-01
Participants
Target number of participants: 120
Treatments
Experimental: Carbetocin
Participants in this arm will receive a single intravenous dose of carbetocin immediately after delivery of the second twin, as prophylaxis for postpartum hemorrhage, following either vaginal or cesarean delivery.
Active_comparator: Oxytocin (Standard Care)
Participants in this arm will receive standard prophylactic oxytocin according to institutional protocol, following either vaginal or cesarean delivery.
Related Therapeutic Areas
Sponsors
Leads: Sheba Medical Center

This content was sourced from clinicaltrials.gov