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Early Neonatal Outcomes After Delayed Versus Immediate Cord Clamping in Preterm Birth: A Comparative Study From A Tunisian Tertiary Maternity Center

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth. Preterm infants are at higher risk of neonatal complications, and the timing of cord clamping may influence placental transfusion and neonatal adaptation after birth. Delayed cord clamping may increase blood volume, improve iron stores, and reduce some neonatal morbidities, while immediate cord clamping is still commonly practiced in many settings. In this study, preterm newborns are assigned to either delayed or immediate cord clamping according to a predefined protocol. Early neonatal outcomes, including respiratory status, need for resuscitation, hemoglobin levels, and early morbidity and mortality, will be assessed. The study is conducted in a tertiary maternity center in Tunisia.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Preterm neonates born at gestational age between 32 and 37 weeks

• Live-born infants delivered in the study center

• Singleton pregnancies

• Parental consent obtained when applicable according to institutional ethical requirements

Locations
Other Locations
Tunisia
Maternity and neonatology center of Tunis
RECRUITING
Tunis
Contact Information
Primary
Mohammed Amine MA Hannachi, Assistant professor
mohammedamine.hannachi@fmt.utm.tn
+21699696332
Backup
Khaled Neji, Professor
DRKHALEDNEJI21@GMAIL.COM
+21651352742
Time Frame
Start Date: 2025-10-02
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 200
Treatments
Experimental: Delayed Umbilical Cord Clamping
Delayed umbilical cord clamping is performed in preterm infants according to the study protocol. The umbilical cord is clamped after a predefined delay following birth (at least 30 seconds), allowing continued placental transfusion to the neonate before cord clamping. The intervention is applied immediately after delivery while ensuring neonatal stabilization according to standard clinical practice.
Experimental: Immediate Umbilical Cord Clamping
Immediate umbilical cord clamping is performed in preterm infants according to standard practice. The umbilical cord is clamped shortly after birth without intentional delay, typically within seconds of delivery, before significant placental transfusion occurs. Neonatal care is provided immediately after clamping according to routine clinical protocols.
Sponsors
Leads: Faculty of Medicine of Tunis

This content was sourced from clinicaltrials.gov