DEVELOPMENT OF A NOVEL STRESS TESTING PROTOCOL TO DEFINE THE RELATIONSHIP BETWEEN CORONARY MICROVASCULAR DYSFUNCTION AND DIASTOLOGY IN WOMEN WITH ANGINA BUT NO EVIDENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of stress maneuvers in conjunction with advanced cardiac magnetic resonance imaging.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• Fully understanding and willing to undergo study procedures

• Male or Female greater than or equal to 18 years of age

• Understanding and willing to sign consent form.

Locations
United States
California
Cedars-Sinai Medical Center
RECRUITING
Los Angeles
Contact Information
Primary
Barbra Streisand Women's Heart Center
310-423-9666
Time Frame
Start Date: 2014-11
Estimated Completion Date: 2030-12
Participants
Target number of participants: 30
Treatments
Experimental: Women w/microvascular disease
10 women with microvascular disease
Experimental: Normal controls
10 age-matched women with no evidence of microvascular disease
Experimental: calibration
10 healthy individuals who will help to synchronize our imaging and stress testing maneuvers.
Related Therapeutic Areas
Sponsors
Leads: Cedars-Sinai Medical Center

This content was sourced from clinicaltrials.gov