Molecular Profiling for Tumor Characterization and Risk Stratification in Patients With Appendiceal Cancer
This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations with clinicopathologic features, and develop molecular risk scores for prognostic stratification. The primary goal is to determine whether DNA methylation- and m6A-based molecular features can complement conventional histopathologic grading and improve risk stratification.
• Patients with histologically confirmed appendiceal adenocarcinoma or appendiceal cancer.
• Availability of archived tumor tissue suitable for molecular profiling.
• Availability of tissue for DNA methylation profiling, m6A epitranscriptomic profiling, or both.
• Availability of relevant clinicopathologic data.
• Availability of survival or follow-up information when applicable.
• Age 18 years or older at diagnosis or tissue collection.