Analysis of Muscle Morphological and Electromechanical Properties in Patients With MFS and EDS: a Low-risk Intervention Study

Status: Active_not_recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS). the main questions it aims to answer are: * To assess the ability to develop muscle strength; * Muscle and tendon morphology involved in muscle contractions/relaxation; * Neuromuscular functionality. Participants will be take part in the study by performing a test for the assessment of the neuromuscular activity (voluntary muscle contractions) and undergoing a muscle ultrasound for the study of muscles and tendons. Researchers will compare the two groups with a control group to see potential differences in the morphological and neuromuscular structures of syndromic patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Healthy Volunteers: t
View:

• Diagnosis of Marfan syndrome or Ehlers Danlos syndrome currently in follow-up at Cardiovascular Genetic Centre IRCCS Policlinico San Donato;

• Signed informed consent;

Locations
Other Locations
Italy
IRCCS Policlinico San Donato
San Donato Milanese
Time Frame
Start Date: 2023-02-15
Completion Date: 2026-01
Participants
Target number of participants: 65
Treatments
MFS_f
Patients with Marfan syndrome with fatigue
MFS_nf
Patients with Marfan syndrome without fatigue
EDS_f
Patients with Ehlers Danlos syndrome with fatigue
EDS_nf
Patients with Ehlers Danlos syndrome without fatigue
Volunteers
Healthy adult volunteers without fatigue
Sponsors
Collaborators: University of Milan
Leads: IRCCS Policlinico S. Donato

This content was sourced from clinicaltrials.gov