Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

Status: Recruiting
Location: See all (18) locations...
Intervention Type: Device, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a prospective, multi-center, two-arm, randomized trial to quantify the performance of the EchoMark®/EchoSure® System for AVF diagnostic ultrasound when used under a protocol of biweekly use for assessing fistula maturation and reducing time to Clinical Maturation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 84
Healthy Volunteers: f
View:

• Males or non-pregnant, non-breastfeeding females ≥ 18 years of age but \< 85 years of age at the time of informed consent.

• Subject is able and willing to provide written informed consent prior to receiving any non-standard of care, protocol specific procedures.

• Subject is willing and capable of complying with all required follow-up visits.

• Subject and/or Care Team agree that the distance and transportation resources from the patient's home to the clinic are reasonable for study participation and compliance.

• Subject has an estimated life expectancy \> 18 months.

• Subject is ambulatory (cane or walker are acceptable).

• CKD Stage 5 (eGFR less than 10) or ESRD subjects presenting for upper arm autologous arteriovenous fistula creation that is not transposed for hemodialysis access.

• Subjects who are currently on dialysis through a CVC or who imminently require dialysis (GFR \<10).

• Vein diameter ≥ 2.5 mm at the antecubital fossa per vein mapping.

• Artery diameter ≥ 2.5 mm per vein mapping.

• Subject is not participating in another investigational clinical trial that has not met its primary end point. Participation in post-market registry is acceptable.

Locations
United States
Alabama
Trinity Research Group
RECRUITING
Dothan
Arizona
AKDHC Medical Research Services
RECRUITING
Phoenix
Southwest Kidney Institute
RECRUITING
Phoenix
Florida
Orlando Health Heart and Vascular Institute
RECRUITING
Orlando
Illinois
Northwestern University
RECRUITING
Chicago
Massachusetts
Boston Medical Center
RECRUITING
Boston
Michigan
MSU Health Care Heart and Vascular
RECRUITING
Lansing
North Carolina
Atrium Health
RECRUITING
Concord
New Jersey
Capital Medical Center
RECRUITING
Pennington
New York
Northwell Health
RECRUITING
New Hyde Park
South Carolina
Prisma Health
RECRUITING
Greenville
Medical University of South Carolina Health Orangeburg
RECRUITING
Orangeburg
Tennessee
Galen Medical Group
RECRUITING
Chattanooga
Fresenius Vascular Care Memphis MSO
TERMINATED
Memphis
Texas
Baylor Scott & White Heart and Vascular Hospital
RECRUITING
Dallas
Aqua Research Institute Llc
RECRUITING
Houston
Virginia
Physicians Care of Virginia
RECRUITING
Roanoke
Sentara Health
RECRUITING
Virginia Beach
Contact Information
Primary
Katy Feeny
kfeeny@sonavex.com
443-862-2024
Time Frame
Start Date: 2024-02-21
Estimated Completion Date: 2026-02-01
Participants
Target number of participants: 304
Treatments
Experimental: Diagnostic Arm
All subjects will have the EchoMark implanted. Subjects will be assessed every 2 weeks (+/- 1 week) (but no more frequently than weekly) with the EchoSure system until fistula maturation occurs and/or permanent access use is achieved.
Active_comparator: Standard of Care
Subjects will be evaluated per KDOQI guidelines (with physical examination at approximately 2 weeks (+/- 1 week) and between 4 and 6 weeks (+/- 1 week)). If evaluation yields abnormal findings, subjects will receive a Duplex ultrasound assessment (DUS). All SOC Arm subjects will be followed per the institution's standard of care until fistula maturation occurs and/or permanent access use is achieved but no more frequently than once per month.
Sponsors
Leads: Sonavex, Inc.

This content was sourced from clinicaltrials.gov