Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT

• No history of stroke, Marfan syndrome, polycystic kidney disease

Locations
Other Locations
China
Jiangsu Province Hospital
ACTIVE_NOT_RECRUITING
Nanjing
the First Affiliated Hospital of Nanjing Medical University
RECRUITING
Nanjing
Contact Information
Primary
Yifei Wang
wangyifei5323@163.com
+86-13852665323
Time Frame
Start Date: 2025-06-13
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 200
Treatments
pAVM with ruptured flow-related aneurysm
pAVM without ruptured flow-related aneurysm
Related Therapeutic Areas
Sponsors
Leads: The First Affiliated Hospital with Nanjing Medical University

This content was sourced from clinicaltrials.gov