• Voluntary participation and signature of informed consent form;.

• ≥ 18 years of age, male or female.

• Participants with histologically and/or cytologically confirmed advanced/metastatic solid tumors;.

• Failure of at least one line of standard systemic anti-tumor therapy, unsuitability for standard systemic therapy, or absence of standard systemic therapy options.

• Moderate or greater ascites confirmed by ultrasonography

• ECOG performance status of 0, 1or 2.

• Life expectancy ≥ 3 months.

• Adequate hematologic and organ function.

• Women of childbearing potential (WOCBP) must have a negative serum pregnancy test. WOCBP and male subjects agree to use adequate contraception.