Impact of Sleep Duration on Immune Balance in Urban Children With Asthma

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Urban children with asthma are at high risk for short sleep, due to an environment that jeopardizes both sleep and asthma management. Further, urban children with asthma suffer from altered immune balance, a key biological process contributing to individual differences in asthma morbidity and sleep health. In the proposed research, the researchers will examine the effects of shortened and recovery sleep on immune balance and associated changes in lung function in urban children with allergic asthma through an experimental design.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Maximum Age: 11
Healthy Volunteers: f
View:

• Children 7-11 years old

• Has physician-diagnosed asthma, per parent and pediatrician report

• Meets criteria for current persistent asthma with a current prescription for an asthma controller medicine

• Obtains 9.0-11.0 h of sleep per 24 h day in the past month

• Has a positive allergy skin test performed at the clinic visit

• Resides and attend school in one of the targeted urban areas (Rhode Island: East Providence, North Providence, Providence, Warwick, Cranston, Woonsocket, Central Falls, Pawtucket, Lincoln, Johnston. Massachusetts: Attleboro, North Attleboro, Fall River.

• Has a primary caregiver who speaks English

Locations
United States
Rhode Island
Rhode Island Hospital
RECRUITING
Providence
Contact Information
Primary
Daphne Koinis-Mitchell, PhD
dkoinismitchell@lifespan.org
401-793-8632
Backup
Sheryl J Kopel, MSc
sjkopel@lifespan.org
401 444-7217
Time Frame
Start Date: 2022-05-15
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 204
Treatments
Experimental: Shortened Sleep
In this 4-week sleep protocol, children in this experimental condition follow a Stabilized Sleep schedule (i.e., their usual bed time) during weeks 1, 3 and 4. During week 2, they follow a Shortened Sleep schedule, during which they go to bed 90 later than is typical.
Active_comparator: Usual Sleep Schedule
In this control arm of the 4-week sleep protocol, children follow the Stabilized Sleep schedule for all 4 weeks.
Related Therapeutic Areas
Sponsors
Collaborators: University of Mississippi Medical Center, Brown University
Leads: Rhode Island Hospital

This content was sourced from clinicaltrials.gov