• Patient must be 18 to 80 years of age inclusive

• Documented physician diagnosis of asthma for at least 12 months, with objective evidence of asthma (spirometric, bronchial challenge, exercise challenge or therapeutic response) within the last 5 years

⁃ 4\. Uncontrolled asthma (i.e. ACQ-6 ≥ 1.5)

⁃ 5\. Pre-BD FEV1 ≥ 40%

⁃ 7\. A history of asthma exacerbations within the last 12 months

⁃ 8\. \& 9. Compliant with asthma background mediation, daily ePROs and daily home spirometry.

⁃ 10\. BMI within the range 18-37 kg/m2 (inclusive)

⁃ 11\. Female patients of child bearing potential must not be pregnant and agree to use highly effective contraception.

⁃ 12\. Male patients and their female partners of childbearing potential must agree to use highly effective contraception.

⁃ 13\. Capable of giving signed informed consent.