ToolCAP: Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia

Status: Recruiting
Location: See all (9) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The ToolCAP study aims to see if using ultrasound to look at the lungs when children have symptoms of a lung infection will safely allow doctors to improve how they treat those infections. The study will also look at if it's possible to improve how doctors decide which children need antibiotics. * Lung infections are the most common reason for children to go to the clinic/hospital. * Doctors usually give an antibiotic to every child with a lung infection. * Lung infections can be caused by 2 different types of germs - bacteria or viruses. * Antibiotics only work against bacteria and not against viruses. Lung infections caused by viruses don't need antibiotics as the body fights them by itself. * Lots of research now shows that only 1 in 4 children with a lung infection actually needs an antibiotic, as the rest only have a viral infection causing the symptoms. * This means that 3 in 4 children get an antibiotic when they don't need it. * Taking too many antibiotics can cause problems for children as it can cause diseases like diabetes or asthma. * Nowadays, due to too many people using too many antibiotics, experts are starting to worry that bacteria are starting to become resistant (stronger than the antibiotic). * Ultrasound of the lungs appears to be a way of safely looking at the lungs to see if there is an infection and may help doctors better decide who needs an antibiotic. This study includes children aged 2 months-12 years who come to the hospital with a lung infection. Children who are very unwell or who have already had 2 days of antibiotic treatment will not be allowed to be in the study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 2 months
Maximum Age: 12
Healthy Volunteers: f
View:

• Cough OR Difficulty Breathing AND,

• One of the below:

⁃ Fast breathing (tachypnoea) \> 50/minute (2-12 months) \> 40/minute (1-\<5 years) \> 25/minute (5-12 years) OR Lower chest wall indrawing

Locations
Other Locations
Senegal
Centre De Santé Gaspard Kamara
RECRUITING
Dakar
Centre National Hospitalier d'Enfants Albert Royer
RECRUITING
Dakar
Université Cheikh Anta Diop
RECRUITING
Dakar
South Africa
Tintswalo Hospital
RECRUITING
Acornhoek
Themba Hospital
RECRUITING
Mbombela
University of Witwatersrand, MRC/Wits Rural Public Health and Health Transitions Research Unit
RECRUITING
Parktown
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University
RECRUITING
Parow
United Republic of Tanzania
Muhimbili University of Health and Allied Sciences
RECRUITING
Dar Es Salaam
Ifakara Health Institute
NOT_YET_RECRUITING
Ifakara
Contact Information
Primary
Kristina Keitel, MD, PhD
Kristina.Keitel@witshealth.co.za
+41763432520
Backup
Jacques du Toit, MD
jacques.dutoit1@wits.ac.za
+27636874914
Time Frame
Start Date: 2025-04-04
Estimated Completion Date: 2026-12
Participants
Target number of participants: 3500
Treatments
Active_comparator: Routine Care Group
This group receives normal routine care. No intervention.
Experimental: Intervention Group
Participants will undergo lung ultrasound and the ultrasound images/videos will be reviewed by an expert and the findings, along with advice on whether or not an antibiotic should be used.~This means in this group there is a chance the participant will not be given an antibiotic if the ultrasound shows there is no need for it.
Related Therapeutic Areas
Sponsors
Leads: University of Bern
Collaborators: National Institute for Medical Research, Tanzania, Muhimbili University of Health and Allied Sciences, Cheikh Anta Diop University, Senegal, University of Stellenbosch, Swiss Tropical & Public Health Institute, University of Witwatersrand, South Africa

This content was sourced from clinicaltrials.gov

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