⁃ Sign the informed consent form before the trial to fully understand the purpose, process and possible adverse reactions of the trial;

⁃ Age 18 \

• 75 years old, gender is not limited;

⁃ Documented physician diagnosis of asthma at least 12 months prior to Visit 1;

⁃ Subjects who received high-dose Inhaled Corticosteroids (ICS) in asthma control medications prescribed by their physicians at least 6 months prior to Visit 1;

⁃ There must be a record of receiving a stable total daily dose of ICS at least 3 months prior to visit 1;

⁃ There must be a record of the use of other asthma control medications at a stable dose at least 3 months prior to visit 1; For subjects taking maintenance oral hormones, the dose of oral hormones is up to 10mg prednisone per day or 20mg every other day (or equivalent) and must be stable for at least 30 days prior to visit 1 and during treatment.

⁃ Documented at least 2 asthma exacerbations in the 12 months prior to Visit 1 and no major asthma exacerbation events in the 1 month prior to signing informed.