A Retrospective Survey Of The Time Course And Nature Of The Experience Of Initiating Biologic Treatment For People With Severe Asthma.

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Severe asthma is a disease characterised by respiratory and non-respiratory symptoms. The respiratory symptoms can include breathlessness, wheeze and asthma attacks. The disease can come to dominate patients' lives, impacting their social, working and personal lives, leading to depression, anxiety and feelings of social isolation. There are now 7 different biologic treatments available on the NHS in the UK for severe asthma. These treatments have dramatically changed how severe asthma can be treated. Research has typically focused on the benefits of these drugs from a clinical perspective, e.g., improvements in lung function, blood tests and reduction in frequency of asthma attacks and use of steroid tablets. While these are important outcomes, they do not reflect the experiences of patients receiving these treatments, which can vary greatly. First, not all patients benefit to the same degree. Second for patients who do respond, some respond slower than others. Third while these treatments target respiratory symptoms, some patients report wider benefits, such as reductions in fatigue, depression, ability to engage in family life and other daily activities. Fourth, patients report different side effects when starting these treatments and sometimes for months afterwards, including headaches, fatigue, mental fog and joint pain. These experiences are reported by clinicians and patients, but the extent of these four variations is poorly understood, and potential reasons for them have not been explored. To describe these differences between patients' experiences and begin understanding why they are present, we have co-designed a survey with people who have lived experience of severe asthma who are members of the European Lung Foundation's (ELF) Patient Advisory Group (PAG). This process has resulted in a survey that contains content important to patients and is worded in a way that avoids confusion regarding the meaning of the questions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Receiving a biologic treatment for at least 6 months.

• • But has not been on the treatment for longer than 18 months. Note: In clinical practice, a 12-month trial of biologic treatments is needed before a decision to stop/switch treatment is made. Therefore, our inclusion criteria will capture people who are non-responders to biologic treatments.

Locations
Other Locations
United Kingdom
Royal Devon University Healthcare NHS Foundation Trust
RECRUITING
Exeter
Contact Information
Primary
Joseph Lanario, PhD
joseph.lanario@plymouth.ac.uk
+44 01752 764403
Backup
Alison Kerridge, PhD
alison.kerridge@nhs.net
+44 01392 403055
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 400
Related Therapeutic Areas
Sponsors
Collaborators: Barts Helth NHS Trust, University Hospital Birmingham, Newcastle-upon-Tyne Hospitals NHS Trust, Guy's and St Thomas' NHS Foundation Trust, University of Plymouth, University Hospital Plymouth NHS Trust
Leads: Royal Devon and Exeter NHS Foundation Trust

This content was sourced from clinicaltrials.gov