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PAXT: Pulmonary Imaging of Mild Asthma Using 129Xe MRI and Tc-99-Labeled-Carbon-Imaging (Tc99CImaging)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The goal of this observational study is to better understand how asthma affects the lungs in young adults (ages 17-35) with mild asthma. The main questions it aims to answer are: * Can advanced imaging detect abnormal airway function in people with mild asthma? * Do changes in ventilation imaging correlate with asthma symptoms or quality of life? Researchers will compare hyperpolarized xenon-129 MRI and Technegas (Tc-99m) imaging to see if these techniques reveal more detailed lung abnormalities than standard lung function tests. Participants will: * Complete a single 2-hour visit * Undergo two types of lung imaging: Hyperpolarized xenon-129 MRI (to visualize how air moves in the lungs), Technegas (Tc-99m) imaging (to assess airflow using nuclear medicine) * Perform spirometry and other breathing tests * Answer questionnaires about asthma symptoms and quality of life This study is designed to improve our understanding of subtle changes in lung function that may not be detected by standard tests in people with mild asthma. The findings may lead to better diagnostic tools and more personalized treatment strategies in the future.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 17
Maximum Age: 35
Healthy Volunteers: f
View:

∙ Participants eligible for inclusion in this study must meet all of the following criteria:

• Participant diagnosed with mild (GINA1) asthma by physician

• Participant understands study procedures and is willing to participate in the study as indicated by the participant's signature

• Provision of written, informed consent prior to any study specific procedures

• Males and females 17 to 35 years of age

• Women of childbearing potential (after menarche) must ensure that they are using an effective form of birth control for at least 2 months prior to each imaging visit. Examples of effective birth control include:

‣ True sexual abstinence

⁃ A vasectomized sexual partner

⁃ Implanon®

⁃ Female sterilization by tubal occlusion

⁃ Effective intrauterine device (IUD)/levonogestrel intrauterine system (IUS)

⁃ Depo-Provera™ injections

⁃ Oral contraceptive

⁃ Evra Patch™

⁃ Nuvaring™

Locations
Other Locations
Canada
Robarts Research Institute; The University of Western Ontario
RECRUITING
London
Contact Information
Primary
Grace E Parraga, PhD
gparraga@robarts.ca
519-931-5777
Backup
Angela P Wilson, RRT
awilson@robarts.ca
519-931-5777
Time Frame
Start Date: 2026-03-02
Estimated Completion Date: 2028-12
Participants
Target number of participants: 40
Treatments
Mild Asthma
Related Therapeutic Areas
Sponsors
Collaborators: Cyclomedica Australia PTY Limited
Leads: Dr. Grace Parraga

This content was sourced from clinicaltrials.gov