Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department: A Randomized Control Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults ≥18 years old presenting to the ED with an asthma exacerbation
• Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
• Discharged from the ED with a primary diagnosis of asthma exacerbation
• Initiated systemic corticosteroids during the ED visit
• Must be English or Spanish speaking
Locations
United States
New York
Montefiore Medical Center
RECRUITING
The Bronx
Contact Information
Primary
Mustfa Manzur, MD MPH MS
mmanzur@montefiore.org
718-920-6626
Time Frame
Start Date: 2026-07-23
Estimated Completion Date: 2026-12
Participants
Target number of participants: 182
Treatments
Active_comparator: Single Intramuscular Steroid Injection
Dexamethasone 16mg Intramuscular Single Dose
Active_comparator: Oral Steroid Short Course
Prednisone 60mg PO for 5 Days
Related Therapeutic Areas
Sponsors
Leads: Montefiore Medical Center