Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental surgeons as part of their usual practice in the control group. For the intervention group, periodontal management will be carried out for a maximum of 6 months after randomisation, prolonged by a follow-up of 6 months including a maintenance visit at M9. All patients will have an FDG-PET at M0 and M12 for evaluation of inflammation on carotid atherosclerotic plaques.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 70
Healthy Volunteers: f
View:

• Patients hospitalized for an acute myocardial infarction and included in the Frenchie registry

• Score ≥ 5 on the screening questionnaire for periodontitis

• Six teeth at least (excluding wisdom teeth)

• Consent signature

• Affiliation to a French medical insurance (Sécurité Sociale)

Locations
Other Locations
France
Hôpital Bichat, AP-HP
RECRUITING
Paris
Contact Information
Primary
Philippe Gabriel STEG
gabriel.steg@aphp.fr
01 40 25 80 80
Time Frame
Start Date: 2019-08-02
Estimated Completion Date: 2028-08
Participants
Target number of participants: 210
Treatments
No_intervention: Usual treatment - Control group
The patient is referred to his treating dentist with a diagnosis report of his oral state including his periodontal status.~The usual care usually includes the extraction of non-preservable teeth, the dental prosthesis to replace them and at least one descaling session.
Experimental: Periodontal treatment - Intervention group
Periodontal treatment can last up to 6 months depending on the periodontal state, followed by a follow-up period of at least 6 months including a visit at M9.~Briefly, the intervention group includes initial therapy with information on oral hygiene techniques, scaling and surfacing of dental roots. This initial therapy is followed by a resumption of periodontal clinical measures after 6 weeks. Depending on the degree of improvement of the measurements, the treatment is either completed, or continues with further scaling-surfacing and / or performing one or more periodontal surgeries. Periodontal monitoring period often called maintenance includes repeated sessions of simple scaling whose rate does not exceed 4 per year.
Sponsors
Collaborators: National Research Agency, France
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov