Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this randomized controlled trial is to assess the impact of disclosing a high polygenic risk result for coronary artery disease on change in cardiovascular health over one year.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 75
Healthy Volunteers: f
View:
• Males and females between 40 and 75 years of age capable and willing to provide informed consent
• Participant has high CAD PRS as defined on a clinical test
Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Contact Information
Primary
Roukoz Abou-Karam, MD
proact@mgb.org
(617)-643-4842
Time Frame
Start Date: 2023-12-07
Estimated Completion Date: 2027-05-01
Participants
Target number of participants: 200
Treatments
Experimental: Intervention
Participants will receive their high polygenic risk result for coronary artery disease.
No_intervention: Control
Participants will receive standard of care, and disclosure of high polygenic risk result will be deferred until study completion.
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)